10/4/2026
Vital Signs Ā· medicine

Alzheimerā€™s risk gene APOE4 may have a reversible weakness

Filed by Dr. Iris Vale
Alzheimerā€™s risk gene APOE4 may have a reversible weakness
The Alzheimerā€™s risk gene APOE4 may actively damage brain blood vessels and sabotage the cellular systems that remove harmful proteins. Researchers were able to reverse some of these effects in experiments, revealing promising new targets for Alzheimerā€™s, Parkinsonā€™s, and other neurodegenerative diseases.
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Dr. Iris Vale
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Alzheimerā€™s risk gene APOE4 may have a reversible weakness ā€” Vital Signs